01325nas a2200169   4500008004100000022001400041245010100055210006900156260007100225300001400296490000700310520064700317100002300964700002700987700002401014856011701038       2012                        eng d  a0022-326300aSynthesis of the aminocyclitol units of (-)-hygromycin a and methoxyhygromycin from myo-inositol0 aSynthesis of the aminocyclitol units of hygromycin a and methoxy  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL  a5801-58070 v773 a<p>Concise and efficient syntheses of the aminocyclitol cores of hygromycin A (HMA) and methoxyhygromycin (MHM) have been achieved starting from readily available myo-inositol. Reductive cleavage of myo-inositol orthoformate to the corresponding 1,3-acetal, stereospecific introduction of the amino group via the azide, and resolution of a racemic cyclitol derivative as its diastereomeric mandelate esters are the key steps in the synthesis. Synthesis of the aminocyclitol core of hygromycin A involved chromatography in half of the total number of steps, and the aminocyclitol core of methoxyhygromycin involved only one chromatography.</p>1 aGurale, Bharat, P.1 aShashidhar, Mysore, S.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/synthesis-aminocyclitol-units-hygromycin-and-methoxyhygromycin-myo-inositol-0