01352nas a2200169   4500008004100000022001400041245012200055210006900177260010600246300001400352490000700366520061200373100002400985700002201009700002201031856012901053       2012                        eng d  a0957-416600aAsymmetric synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W from 4-pentenoic acid0 aAsymmetric synthesis of a 12membered macrolactone core and a 6ep  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a1170-11850 v233 a<p>A flexible and efficient asymmetric route to the synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W has been accomplished from commercially available 4-pentenoic acid. The successful generation of stereocenters was achieved by utilizing an Evans' chiral auxiliary-based alkylation and aldol reaction. Other key reactions such as a Julia-Kocienski olefination, Kita's macrolactonization, ring closing metathesis (RCM) reaction, and Yamaguchi's esterification were significant for the construction of the macrolactone cores. (c) 2012 Elsevier Ltd. All rights reserved.</p>1 aChatterjee, Bhaskar1 aMondal, Dhananjoy1 aBera, Smritilekha  uhttps://library.ncl.res.in/content/asymmetric-synthesis-12-membered-macrolactone-core-and-6-epi-analogue-amphidinolide-w-4-0