01560nas a2200169   4500008004100000022001400041245011800055210006900173260010600242300001400348490000700362520081500369100002501184700002601209700002801235856012701263       2012                        eng d  a0957-416600aCarbohydrate-derived conformationally restricted bicyclic dipeptides as potential hetero foldamer building blocks0 aCarbohydratederived conformationally restricted bicyclic dipepti  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a1400-14040 v233 a<p>Starting from carbohydrate precursors, hetero foldamer building blocks featuring diverse amino acid side chains and stereochemistry have been accessed via a multi-step synthetic protocol. These conformationally restricted bicyclic dipeptide building blocks are characterized by a constrained beta-lactam ring fused with a pyrrolidine ring carrying a hydroxyethylamine isostere (HEA) on the backbone. These building blocks offer the possibility of developing foldamers with interesting structural architectures, conspicuously different from those classically observed. Furthermore, such hetero-building blocks have the potential to augment the conformational space available for foldamer design with diverse backbone conformations and structural architectures. (C) 2012 Elsevier Ltd. All rights reserved.</p>1 aRamesh, Veera, V. E.1 aPuranik, Vedavati, G.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/carbohydrate-derived-conformationally-restricted-bicyclic-dipeptides-potential-hetero-0