01256nas a2200169   4500008004100000022001400041245018300055210006900238260011000307300001400417490000700431520043900438100003000877700002600907700002200933856013100955       2013                        eng d  a1477-052000aOptically pure gamma-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: a formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide0 aOptically pure gammabutyrolactones and epoxy esters via two ster  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a1280-12850 v113 a<p>The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(III)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted gamma-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.</p>1 aDevalankar, Dattatray, A.1 aKarabal, Pratibha, U.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/optically-pure-gamma-butyrolactones-and-epoxy-esters-two-stereocentered-hkr-3-substituted-0