01266nas a2200181   4500008004100000022001400041245007800055210006900133260011000202300001400312490000700326520054800333100002300881700003300904700001400937700002200951856011100973       2013                        eng d  a1463-926200aEngaging isatins in solvent-free, sterically congested passerini reaction0 aEngaging isatins in solventfree sterically congested passerini r  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a1608-16140 v153 a<p>A facile, atom-economic and environmentally-benign protocol for the synthesis of biologically important oxindole derivatives in high yields has been demonstrated by employing isatins as carbonyl compound surrogates in a Passerini reaction carried out under solvent-free conditions. Moreover, electron-deficient phenols can also be used as the acid component in this reaction. In addition, the synthetic utility of the present methodology was examined by the one-pot synthesis of oxindoles with a free -OH group at the benzylic position.</p>1 aKaicharla, Trinadh1 aYetra, Santhivardhana, Reddy1 aRoy, Tony1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/engaging-isatins-solvent-free-sterically-congested-passerini-reaction-0