01601nas a2200169   4500008004100000022001400041245014800055210006900203260011000272300001400382490000600396520084900402100001601251700002001267700002201287856012201309       2013                        eng d  a1759-995400aSynthesis of end-functionalized phosphate and phosphonate-polypeptides by ring-opening polymerization of their corresponding N-carboxyanhydride0 aSynthesis of endfunctionalized phosphate and phosphonatepolypept  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAUG  a4087-40910 v43 a<p>Phosphopolypeptides provide an interesting biomimetic analog for phosphorylated proteins that are involved in biomineralization. We have developed a high yielding synthesis of cysteine-based phosphate and phosphonate N-carboxyanhydride (NCA) by using the thiol-ene coupling reaction. These phosphate and phosphonate NCA monomers underwent polymerization using simple primary amine initiators to form well defined homophosphopolypeptides. Using a bifunctional initiator we were able to install a ``clickable'' alkyne or azide group at the end of the polypeptide chain. We were also able to successfully synthesize fully water-soluble phosphonate based polypeptides by hydrolysis of the corresponding phosphonate ester groups in the polypeptide. These water-soluble phosphopolypeptides adopt a random coil conformation at physiological pH.</p>1 aDas, Soumen1 aKar, Mrityunjoy1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-end-functionalized-phosphate-and-phosphonate-polypeptides-ring-opening-0