01829nas a2200145   4500008004100000022001400041245009200055210006900147260010400216300001100320520118700331100002601518700002101544856011801565       2013                        eng d  a2314-613300aBiosurfactant-sophorolipid acts in synergy with antibiotics to enhance their efficiency0 aBiosurfactantsophorolipid acts in synergy with antibiotics to en  a410 PARK AVENUE, 15TH FLOOR, \#287 PMB, NEW YORK, NY 10022 USAbHINDAWI PUBLISHING CORPORATIONcAPR  a5124953 a<p>Sophorolipids (SLs), biosurfactants with antimicrobial properties, have been tried to address the problem of antibiotic resistance. The synergistic action of SL and antibiotics was checked using standard microdilution and spread plate methods. With Staphylococcus aureus, SL-tetracycline combination achieved total inhibition before 4 h of exposure while tetracycline alone couldnot achieve total inhibition till the end of 6 h. The inhibition caused by exposure of bacterium to SL-tetracycline mixture was similar to 25% more as compared to SL alone. In spite of known robustness of gram-negative bacteria, SL-cefaclor mixture proved to be efficient against Escherichia coli which showed similar to 48% more inhibition within 2 h of exposure as compared to cefaclor alone. Scanning electron microscopy of the cells treated with mixture revealed bacterial cell membrane damage and pore formation. Moreover, SLs being a type of asymmetric bola, they are expected to form self-assemblies with unique functionality. This led to the speculation that SLs being amphiphilic in nature can span through the structurally alike cell membrane and facilitate the entry of drug molecules.</p>1 aJoshi-Navare, Kasturi1 aPrabhune, Asmita  uhttps://library.ncl.res.in/content/biosurfactant-sophorolipid-acts-synergy-antibiotics-enhance-their-efficiency-0