01757nas a2200157   4500008004100000022001400041245015200055210006900207260005700276300001400333490000700347520107700354100002101431700002001452856012701472       2013                        eng d  a0022-246100aGlycolic acid-functionalized chitosan-Co3O4-Fe3O4 hybrid magnetic nanoparticles-based nanohybrid scaffolds for drug-delivery and tissue engineering0 aGlycolic acidfunctionalized chitosanCo3O4Fe3O4 hybrid magnetic n  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcFEB  a1524-15320 v483 a<p>In the present work, Co3O4 was prepared by hydrothermal process, which is further used for the synthesis of Co3O4-Fe3O4 hybrid nanoparticles. The formation of Co3O4-Fe3O4 nanoparticles was investigated by transmission electron microscopy and physical property measurement system. In the next step, the drug-loaded novel nanohybrid porous scaffold based on chitosan-g-glycolic acid and Co3O4-Fe3O4 nanoparticle was prepared by freeze drying technique. The grafting of glycolic acid on chitosan drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of the pH of the medium and play an important role in cell adhesion, proliferation, and migration. Co3O4-Fe3O4 hybrid nanoparticles' reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Co3O4-Fe3O4 hybrid nanoparticles are viable additives for formulating sustained drug delivery systems and could be applied in the field of biomaterials.</p>1 aKumari, Sangeeta1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/glycolic-acid-functionalized-chitosan-co3o4-fe3o4-hybrid-magnetic-nanoparticles-based-0