01665nas a2200241   4500008004100000022001400041245005200055210005200107260011100159300001200270490000700282520083700289653002201126653002001148653003101168653001501199653003601214653001301250100002601263700002201289700002601311856008601337       2013                        eng d  a1389-557500aChitin synthase inhibitors as antifungal agents0 aChitin synthase inhibitors as antifungal agents  aEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATESbBENTHAM SCIENCE PUBL LTDcFEB  a222-2360 v133 a<p>Increased risk of fungal diseases in immunocompromised patients, emerging fungal pathogens, limited repertoire of antifungal drugs and resistance development against the drugs demands for development of new and effective antifungal agents. With greater knowledge of fungal metabolism efforts are being made to inhibit specific enzymes involved in different biochemical pathways for the development of antifungal drugs. Chitin synthase is one such promising target as it is absent in plants and mammals. Nikkomycin Z, a chitin synthase inhibitor is under clinical development. Chitin synthesis in fungi, chitin synthase as a target for antifungal agent development, different chitin synthase inhibitors isolated from natural sources, randomly synthesized and modified from nikkomycin and polyoxin are discussed in this review.</p>10aAntifungal agents10aChitin synthase10aChitin synthase inhibitors10aNikkomycin10aPeptidyl nucleoside antibiotics10aPolyoxin1 aChaudhary, Preeti, M.1 aTupe, Santosh, G.1 aDeshpande, Mukund, V.  uhttps://library.ncl.res.in/content/chitin-synthase-inhibitors-antifungal-agents-0