01177nas a2200229   4500008004100000022001400041245010100055210006900156260007700225300001400302490000900316520034500325653001300670653001500683653001200698653002200710653002000732653002100752100003100773700001900804856012400823       2013                        eng d  a1434-193X00aTotal synthesis of umuravumbolide and hyptolide through silicon-tethered ring-closing metathesis0 aTotal synthesis of umuravumbolide and hyptolide through silicont  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJUL  a4586-45930 v20133 a<p>The total synthesis of umuravumbolide and hyptolide has been achieved in a efficient manner by using temporary silicon-tethered ring-closing metathesis and cross-coupling reactions as key steps. The stereogenic centres were generated by means of proline-catalysed -aminoxylation of aldehydes and Brown's asymmetric allylation method.</p>10alactones10aMetathesis10aSilanes10asynthetic methods10aTotal synthesis10aWittig reactions1 aChowdhury, Partha, Sarathi1 aKumar, Pradeep  uhttps://library.ncl.res.in/content/total-synthesis-umuravumbolide-and-hyptolide-through-silicon-tethered-ring-closing-0