01799nas a2200229   4500008004100000022001400041245008700055210006900142260011000211300001400321490000700335520090100342653003301243653002401276653003001300653001801330653002901348100002301377700002401400700002901424856011601453       2013                        eng d  a0376-471000aSynthesis and fluorescence properties of a full set of extended RNA base analogues0 aSynthesis and fluorescence properties of a full set of extended   aDR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIAbNATL INST SCIENCE COMMUNICATION-NISCAIRcAUG  a1004-10130 v523 a<p>The synthesis and photophysical characterization of a complete set of fluorescent RNA base analogues derived by conjugating benzofuran moiety at the 5- and 8-positions of pyrimidine and purine bases, respectively, are described. Benzofuran-modified pyrimidine and purine ribonucleoside analogues exhibit Contrasting fluorescence properties. Pyrimidine analogues are moderately emissive with emission maximum in the visible region, and importantly, are highly sensitive to solvent polarity and Viscosity changes. On the other hand, purine analogues are highly emissive and are minimally affected by solvation. and viscosity effects. Thorough photophysical analysis reveals that the pyrimidine and purine ribonucleosides displaying distinct and-probe-like fluorescence properties could be useful in designing nucleic acid based biophysical tools to study nucleic acid structure and function.</p>10aEnvironment sensitive probes10aFluorescence probes10aFluorescence spectroscopy10aNucleic acids10aRibonucleoside analogues1 aSabale, Pramod, M.1 aNuthanakanti, Ashok1 aSrivatsan, Seergazhi, G.  uhttps://library.ncl.res.in/content/synthesis-and-fluorescence-properties-full-set-extended-rna-base-analogues-0