01339nas a2200157   4500008004100000022001400041245012400055210006900179260011000248300001400358490000600372520064000378100001701018700001901035856012701054       2014                        eng d  a2046-206900aDimethyl homophthalates to naphthopyrans: the total synthesis of arnottin I and the formal synthesis of (-)-arnottin II0 aDimethyl homophthalates to naphthopyrans the total synthesis of   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a5531-55350 v43 a<p>A simple and efficient 3-step synthetic protocol has been reported for dimethyl homophthalates to naphthopyrans. Starting from dimethyl 2,3-dimethoxyhomophthalate, a practical synthesis of arnottin I has been described via a base catalyzed mono-alkylation, the selective hydrolysis of an aliphatic ester moiety, two consecutive intramolecular cyclizations and an oxidative aromatization pathway with a very good overall yield. The involved intramolecular acylation followed by an associated enolative lactonization was the decisive step. The synthesis of dihydroarnottin I also completes the formal synthesis of (-)-arnottin II.</p>1 aJangir, Ravi1 aArgade, N., P.  uhttps://library.ncl.res.in/content/dimethyl-homophthalates-naphthopyrans-total-synthesis-arnottin-i-and-formal-synthesis-0