02059nas a2200145   4500008004100000022001400041245013800055210006900193260009700262300001100359520137300370100002201743700002101765856012701786       2014                        eng d  a1537-744X00aNovel glycolipids synthesized using plant essential oils and their application in quorum sensing inhibition and as antibiofilm agents0 aNovel glycolipids synthesized using plant essential oils and the  a410 PARK AVENUE, 15TH FLOOR, \#287 PMB, NEW YORK, NY 10022 USAbHINDAWI PUBLISHING CORPcJAN  a8907093 a<p>Essential oils (EOs) form an important part of traditional medicine so their anti-microbial and, in the recent past, antiquorum sensing activity has been well studied. However it is likely that due to their hydrophobic nature and reduced solubility in aqueous environments full potential of their activity cannot be realized. hence it is only rational to formulate a process to make these molecules more polar in nature. The present paper reports synthesis of sophorolipids using 12 different essential oils as substrates, thus providing surfactant-like properties to these EOs. The synthesis protocol makes the use of Candida bombicola ATCC 22214 as producer organism. The production process required 7 days of incubation at 28 degrees C and 180 rpm. Preliminary characterization of the synthesized essential oil sophorolipids (EOSLs) was performed using thin layer chromatography (TLC) and Fourier transform infrared spectroscopy (FTIR). Additionally, essential oils that were incapable of mediating quorum sensing inhibition (QSI) on their own became potent quorum sensing inhibitors upon conversion into their corresponding EOSLs. Antibiofilm potential of these EOSLs was also demonstrated using V. cholerae as test organism. Use of essential oils as substrates for glycolipid synthesis has not been attempted previously, and hence this is the first report.</p>1 aMukherji, Ruchira1 aPrabhune, Asmita  uhttps://library.ncl.res.in/content/novel-glycolipids-synthesized-using-plant-essential-oils-and-their-application-quorum-0