01444nas a2200193   4500008004100000022001400041245026000055210006900315260011000384300001400494490000600508520048100514100003100995700002701026700002401053700002401077700001901101856013001120       2014                        eng d  a2046-206900aHighly efficient one-pot multi-component synthesis of alpha-aminophosphonates and bis-alpha-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular eval0 aHighly efficient onepot multicomponent synthesis of alphaaminoph  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a7666-76720 v43 a<p>A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of alpha-aminophosphonate derivatives (4a-x) in excellent yields. The alpha-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.</p>1 aMulla, Shafeek, Abdul Rash1 aPathan, Mohsinkhan, Y.1 aChavan, Santosh, S.1 aGample, Suvarna, P.1 aSarkar, Dhiman  uhttps://library.ncl.res.in/content/highly-efficient-one-pot-multi-component-synthesis-alpha-aminophosphonates-and-bis-alpha-0