01237nas a2200169   4500008004100000022001400041245018500055210006900240260011000309300001400419490000700433520042500440100002600865700002500891700002200916856012900938       2014                        eng d  a1477-052000aCo(III)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: its application in the synthesis of ICI-118,551, an anti-hypertensive agent0 aCoIIIsalencatalyzed phenolic kinetic resolution of two stereocen  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a2349-23550 v123 a<p>The salen Co(III)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti-or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols in excellent yields and ees. The synthetic potential of this protocol is illustrated with an enantioselective synthesis of ICI-118,551, a beta-blocker, in a highly optically pure form (99% ee).</p>1 aKarabal, Pratibha, U.1 aKamble, Dayanand, A.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/coiiisalen-catalyzed-phenolic-kinetic-resolution-two-stereocentered-benzyloxy-and-azido-0