01335nas a2200193   4500008004100000022001400041245010900055210006900164260011000233300001400343490000700357520055400364100001700918700001800935700002400953700001700977700001800994856012901012       2014                        eng d  a1359-734500aAnti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs0 aAnticancer therapeutic potential of quinazoline based small mole  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a4639-46420 v503 a<p>Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structural moiety (2,4-diphenyl-quinazoline) can be used as scaffolds to design activators of miRNA expression paving the way for novel anti-cancer drugs.</p>1 aNahar, Smita1 aBose, Debojit1 aPanja, Sumit, Kumar1 aSaha, Satyen1 aMaiti, Souvik  uhttps://library.ncl.res.in/content/anti-cancer-therapeutic-potential-quinazoline-based-small-molecules-global-upregulation-0