01397nas a2200169   4500008004100000022001400041245010900055210006900164260011000233300001400343490000700357520066900364100001801033700002401051700002101075856013101096       2014                        eng d  a1477-052000aTotal synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus flammulina velutipes0 aTotal synthesis of an anticancer norsesquiterpene alkaloid isola  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a4098-41030 v123 a<p>The first total synthesis of a norsesquiterpene alkaloid (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclo-penta[e]isoindole-1,3(2 H,6H)-dione, isolated from the mushroom-forming fungus Flammulina velutipes, in both racemic and enantiomeric pure forms, is reported. The (-)-enantiomer of the natural product has been synthesized from the D-(-)-pantolactone chiral pool. The synthesis features a one-pot, three-step reaction sequence comprising an enyne RCM/Diels-Alder/aromatization to construct the desired indane skeleton present in the natural product. Our synthesis further confirms the assigned structure and absolute configuration of the natural product.</p>1 aKashinath, K.1 aJadhav, Prakash, D.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/total-synthesis-anticancer-norsesquiterpene-alkaloid-isolated-fungus-flammulina-velutipes-0