01320nas a2200169   4500008004100000022001400041245010800055210006900163260011000232300001600342490000600358520058800364100002200952700002200974700002600996856012801022       2014                        eng d  a2046-206900aSmallest organocatalyst in highly enantioselective direct aldol reaction in wet solvent-free conditions0 aSmallest organocatalyst in highly enantioselective direct aldol   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a24311-243150 v43 a<p>The catalytic efficacy of the smallest organocatalyst, L-proline hydrazide, prepared from a cheaply available natural amino acid, such as L-proline, was studied for the direct asymmetric aldol reaction of various ketones with aromatic aldehydes at room temperature in the presence of several acid additives. A loading of 10 mol% of catalyst 1 and p-toluenesulphonic acid as an additive was employed in this reaction, and good yields (up to 99%) with high anti/syn diastereoselectivities (up to 95 : 5) and enantioselectivities (up to &gt;99.9%) were achieved in aqueous media.</p>1 aBhowmick, Sudipto1 aKunte, Sunita, S.1 aBhowmick, Kartick, C.  uhttps://library.ncl.res.in/content/smallest-organocatalyst-highly-enantioselective-direct-aldol-reaction-wet-solvent-free-0