01251nas a2200157   4500008004100000022001400041245015000055210006900205260011000274300001600384490000600400520052800406100002300934700002200957856011400979       2014                        eng d  a2046-206900aSimple and efficient synthesis of isocoumarins and alkylidenephthalides from 3-(1-hydroxycarbethoxy/alkyl)phthalides with a DEAD/PPh3/TBHP system0 aSimple and efficient synthesis of isocoumarins and alkylidenepht  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a57658-576610 v43 a<p>A facile and novel approach to the synthesis of 3-carbethoxy-isocoumarins and 3-alkylidenephthalides is described. The methodology employs DEAD/PPh3/TBHP as the reagent system proceeding through unprecedented 1,2-shift intramolecular ring expansion or simple elimination depending upon substituents present on 3-substituted phthalides, with broader substrate scope. This strategy is amply demonstrated in the short synthesis of bioactive molecules such as cytogenin and (Z)-3-butylidene-7-hydroxy-5-methoxyphthalide.</p>1 aGadakh, Sunita, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/simple-and-efficient-synthesis-isocoumarins-and-alkylidenephthalides-3-1-0