01512nas a2200157   4500008004100000022001400041245012700055210006900182260007100251300001400322490000600336520084200342100002401184700001801208856012801226       2014                        eng d  a1948-718500aExperimental determination of the electrostatic nature of carbonyl hydrogen-bonding interactions using IR-NMR correlations0 aExperimental determination of the electrostatic nature of carbon  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAUG  a3211-32150 v53 a<p>Hydrogen-bonding plays a fundamental role in the structure, function, and dynamics of various chemical and biological systems. Understanding the physical nature of interactions and the role of electrostatics in hydrogen-bonding has been the focus of several theoretical and computational research. We present an experimental approach involving IR-C-13 NMR correlations to determine the electrostatic nature of carbonyl hydrogen-bonding interactions. This report provides a direct experimental evidence of the classical nature of hydrogen-bonding interaction in carbonyls, independent of any theoretical approximation. These results have important implications in chemistry and biology and can be applied to probe the reaction mechanisms involving carbonyl activation/stabilization by hydrogen bonds using spectroscopic techniques.</p>1 aKashid, Somnath, M.1 aBagchi, Sayan  uhttps://library.ncl.res.in/content/experimental-determination-electrostatic-nature-carbonyl-hydrogen-bonding-interactions-0