01566nas a2200169   4500008004100000022001400041245012800055210006900183260010600252300001400358490000700372520081800379100002201197700002201219700002601241856012901267       2014                        eng d  a0957-416600aNew organocatalyst derived from abietic acid and 4-hydroxy-L-proline for direct asymmetric aldol reactions in aqueous media0 aNew organocatalyst derived from abietic acid and 4hydroxyLprolin  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a1292-12970 v253 a<p>Enantioselective direct aldol reactions were carried out in aqueous media with a new organocatalyst that was derived from 4-hydroxy-L-proline and abietic acid via a simple and convenient synthetic protocol with a high overall yield (75%). The new organocatalyst was used for aldol reactions between substituted aromatic aldehydes and various ketones in the presence of several acid additives in aqueous media. The corresponding aldol products were obtained in high isolated yields (up to 99%) and with high anti-diastereoselectivities (up to 94%) and enantioselectivities (&gt;99.9%). The catalyst loading can be efficiently reduced to only 1 mol %. The aldol reactions were found to be extremely fast which is very unusual in organocatalyzed reactions in water. (C) 2014 Elsevier Ltd. All rights reserved.</p>1 aBhowmick, Sudipto1 aKunte, Sunita, S.1 aBhowmick, Kartick, C.  uhttps://library.ncl.res.in/content/new-organocatalyst-derived-abietic-acid-and-4-hydroxy-l-proline-direct-asymmetric-aldol-0