01551nas a2200157   4500008004100000022001400041245007600055210006900131260009100200300002600291490000600317520092900323100002201252700001501274856010401289       2014                        eng d  a1932-620300aEffect of gold nanoparticle on structure and fluidity of lipid membrane0 aEffect of gold nanoparticle on structure and fluidity of lipid m  a1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USAbPUBLIC LIBRARY SCIENCEcDEC  aArticle No. : e1141520 v93 a<p>This paper deals with the effect of different size gold nanoparticles on the fluidity of lipid membrane at different regions of the bilayer. To investigate this, we have considered significantly large bilayer leaflets and incorporated only one nanoparticle each time, which was subjected to all atomistic molecular dynamics simulations. We have observed that, lipid molecules located near to the gold nanoparticle interact directly with it, which results in deformation of lipid structure and slower dynamics of lipid molecules. However, lipid molecules far away from the interaction site of the nanoparticle get perturbed, which gives rise to increase in local ordering of the lipid domains and decrease in fluidity. The bilayer thickness and area per head group in this region also get altered. Similar trend, but with different magnitude is also observed when different size nanoparticle interact with the bilayer.</p>1 aMhashal, Anil, R.1 aRoy, Sudip  uhttps://library.ncl.res.in/content/effect-gold-nanoparticle-structure-and-fluidity-lipid-membrane-0