01833nas a2200157   4500008004100000022001400041245015200055210006900207260011000276300001200386490000700398520110000405100001901505700002501524856012601549       2015                        eng d  a1744-683X00aBeta self-association and adsorption on a hydrophobic nanosurface: competitive effects and the detection of small oligomers via electrical response0 aBeta selfassociation and adsorption on a hydrophobic nanosurface  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a269-2790 v113 a<p>Treatment of Alzheimer's disease (AD) is impeded by the lack of effective early diagnostic methods. Small, soluble A beta globulomers play a major role in AD neurotoxicity, and detecting their presence in aqueous fluids could lead to suitable sensors. We evaluate the adsorption behavior of small A beta oligomers on the surface of a single walled carbon nanotube of high curvature. While the intrinsic self-assembly propensity of A beta is markedly hindered by adsorption, the oligomeric units show high degrees of surface immobilization. Immobilized complexes are capable of oligomeric growth, but with a shifted monomer-oligomer equilibrium compared to the free states. In the presence of an ionic solution and suitable external electric fields, magnitudes of the current blockades are found to be sensitive to the oligomeric number of the adsorbed complex. However, this sensitivity gradually diminishes with increasing oligomeric size. The results provide a proof-of-concept basis for further investigations in the design of sensors for detecting the toxic small oligomers of A beta.</p>1 aJana, Asis, K.1 aSengupta, Neelanjana  uhttps://library.ncl.res.in/content/beta-self-association-and-adsorption-hydrophobic-nanosurface-competitive-effects-and-0