01267nas a2200157   4500008004100000022001400041245018300055210006900238260011000307300001600417490000600433520049200439100002500931700002200956856013100978       2015                        eng d  a2046-206900aOne-pot highly enantio- and diastereoselective synthesis of anti,anti vinylic 3-amino-1,2 diols via proline catalyzed sequential alpha-amination/benzoyloxyallylation of aldehydes0 aOnepot highly enantio and diastereoselective synthesis of antian  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a21803-218050 v53 a<p>The first direct asymmetric synthesis of anti, anti vinylic 3-amino-1,2-diols from aldehydes is described via a one-pot sequential L-proline catalyzed alpha-amination/benzoyloxyallylation protocol. The reaction proceeds with exceptionally high diastereoselectivity (&gt;99%) as can be explained based on the Felkin-Ahn transition state model. Its effectiveness is proven unambiguously by demonstrating a short asymmetric synthesis of D-ribo-phytosphingosine tetraacetate (93% ee).</p>1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/one-pot-highly-enantio-and-diastereoselective-synthesis-antianti-vinylic-3-amino-12-diols-0