01285nas a2200169   4500008004100000022001400041245015900055210006900214260011000283300001400393490000700407520052100414100001900935700002300954700001800977856012000995       2015                        eng d  a1477-052000aEfficient access to enantiopure 1,3-disubstituted isoindolines from selective catalytic fragmentation of an original desymmetrized rigid overbred template0 aEfficient access to enantiopure 13disubstituted isoindolines fro  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a4438-44480 v133 a<p>An efficient and scalable synthesis of various enantiopure 1,3-disubstituted isoindolines is reported. The base catalyzed nucleophilic fragmentation of a rigid overbred template is established with various substrates to afford the corresponding 1,3-disubstituted isoindoline ester, amide, thioate, 1,3-amino alcohol and isoindolylcarboxylic acid. The crucial rigid overbred template is synthesized in an optically pure form in multigram scale by asymmetric desymmetrization of the corresponding meso compound.</p>1 aPandey, Ganesh1 aVarkhedkar, Rajesh1 aTiwari, Divya  uhttps://library.ncl.res.in/content/efficient-access-enantiopure-13-disubstituted-isoindolines-selective-catalytic-0