01932nas a2200229   4500008004100000022001400041245012600055210006900181260011000250300001400360490000600374520101600380100002701396700002201423700002401445700002201469700002401491700002301515700001801538700002501556856012101581       2015                        eng d  a2050-750X00aCalcium phosphate nanocapsule crowned multiwalled carbon nanotubes for pH triggered intracellular anticancer drug release0 aCalcium phosphate nanocapsule crowned multiwalled carbon nanotub  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a3931-39390 v33 a<p>We report calcium phosphate (CaP) nanocapsule crowned multi-walled carbon nanotubes (CNT-GSH-G4-CaP) as a novel platform for intracellular delivery of an anticancer drug. As a proof-of-concept, CNT-GSH-G4-CaP demonstrates release of anticancer drug doxorubicin hydrochloride (DOX) within intracellular lysosomes from the interior cavity of CNT upon pH triggered CaP dissolution. Importantly, we found that the CNT with a CaP nanolid can efficiently prevent untimely drug release at physiological pH but promotes DOX release at increased acidic milieu as observed in subcellular compartments such as lysosomes (similar to 5.0). This ``zero premature release'' characteristic is of clinical significance in delivering cytotoxic drugs, by reducing systemic toxicity and thus beneficial for the effective anticancer treatment. We envision that this pH triggered CaP crowned CNT nanosystem would lead to a new generation of self-regulated platforms for intracellular delivery of a variety of anticancer drugs.</p>1 aBanerjee, Shashwat, S.1 aTodkar, Kiran, J.1 aKhutale, Ganesh, V.1 aChate, Govind, P.1 aBiradar, Ankush, V.1 aGawande, Manoj, B.1 aZboril, Radek1 aKhandare, Jayant, J.  uhttps://library.ncl.res.in/content/calcium-phosphate-nanocapsule-crowned-multiwalled-carbon-nanotubes-ph-triggered-0