01466nas a2200169   4500008004100000022001400041245002900055210002800084260011000112300001400222490000700236520092600243100002101169700002501190700001801215856006301233       2015                        eng d  a1477-052000aTale of RNA G-quadruplex0 aTale of RNA Gquadruplex  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a5570-55850 v133 a<p>G-quadruplexes are non-canonical secondary structures found in guanine rich regions of DNA and RNA. Reports have indicated the wide occurrence of RNA G-quadruplexes across the transcriptome in various regions of mRNAs and non-coding RNAs. RNA G-quadruplexes have been implicated in playing an important role in translational regulation, mRNA processing events and maintenance of chromosomal end integrity. In this review, we summarize the structural and functional aspects of RNA G-quadruplexes with emphasis on recent progress to understand the protein/trans factors binding these motifs. With the revelation of the importance of these secondary structures as regulatory modules in biology, we have also evaluated the various advancements towards targeting these structures and the challenges associated with them. Apart from this, numerous potential applications of this secondary motif have also been discussed.</p>1 aAgarwala, Prachi1 aPandey, Satyaprakash1 aMaiti, Souvik  uhttps://library.ncl.res.in/content/tale-rna-g-quadruplex-0