01497nas a2200193   4500008004100000022001400041245018800055210006900243260011000312300001400422490000700436520060900443100002201052700002301074700002001097700002701117700002801144856013101172       2015                        eng d  a1144-054600aTris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles0 aTrishydroxymethylaminomethane THAM a novel organocatalyst for a   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a4452-44630 v393 a<p>simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles using a commercially available, inexpensive, non-toxic, and biodegradable tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. Ambient reaction conditions, wide scope, avoidance of conventional isolation as well as purification techniques and the reusability of the catalyst for five consecutive runs have improved the practical utility of this multicomponent reaction protocol manifold.</p>1 aPandit, Kapil, S.1 aChavan, Pramod, V.1 aDesai, Uday, V.1 aKulkarni, Makarand, A.1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/tris-hydroxymethylaminomethane-tham-novel-organocatalyst-environmentally-benign-synthesis-0