01263nas a2200157   4500008004100000022001400041245021300055210006900268260011000337300001400447490000700461520045900468100002100927700002600948856013100974       2015                        eng d  a1477-052000aEfficient one pot regioselective synthesis of a 3,3 `-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones0 aEfficient one pot regioselective synthesis of a 33 spirophosphon  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL  a8669-86750 v133 a<p>A one pot, highly regioselective synthesis of racemic 3,3'-spiro-phosphonylpyrazole-oxindole by 1,3-dipolar cycloaddition of an in situ generated anion of dialkyl 1-diazomethylphosphonate from the Bestmann-Ohira reagent (BOR) &amp; methyleneindolinones has been developed. The synthesis affords the highly functionalized pyrazole scaffolds in good yields with excellent regioselectivity under mild reaction conditions within a short reaction time.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/efficient-one-pot-regioselective-synthesis-33-spiro-phosphonylpyrazole-oxindole-framework-0