01240nas a2200169   4500008004100000022001400041245006100055210005900116260011000175300001600285490000600301520059800307100002300905700002400928700002600952856009200978       2015                        eng d  a2046-206900aEne-nucleic acids: a different paradigm to DNA chemistry0 aEnenucleic acids a different paradigm to DNA chemistry  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a97824-978300 v53 a<p>Acyclic prochiral nucleic acids such as FNA, UNA, GNA and cyclic chiral TNA are all considered as precursors of DNA and RNA in the chemical etiology of nucleic acids. The chemical reasoning would suggest that unsaturated precursors with constrained flexibility and selectivity based on cis/trans isomers could be the missing link between the prochiral-acyclic and chiral-cyclic structures mentioned above. We find that ene-nucleic acids derived from an isoprenoid skeleton possess requisite flexibility and rigidity while forming stable duplex structures with complementary DNA and RNA.</p>1 aVarada, Manojkumar1 aErande, Namrata, D.1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/ene-nucleic-acids-different-paradigm-dna-chemistry-0