02100nas a2200145   4500008004100000022001400041245009300055210006900148260007200217300002700289520146900316100002201785700002101807856012601828       2015                        eng d  a1758-046300aComparison of human cell signaling pathway databases-evolution, drawbacks and challenges0 aComparison of human cell signaling pathway databasesevolution dr  aGREAT CLARENDON ST, OXFORD OX2 6DP, ENGLANDbOXFORD UNIV PRESScJAN  aArticle Number: bau1263 a<p>Elucidating the complexities of cell signaling pathways is of immense importance to gain understanding about various biological phenomenon, such as dynamics of gene/protein expression regulation, cell fate determination, embryogenesis and disease progression. The successful completion of human genome project has also helped experimental and theoretical biologists to analyze various important pathways. To advance this study, during the past two decades, systematic collections of pathway data from experimental studies have been compiled and distributed freely by several databases, which also integrate various computational tools for further analysis. Despite significant advancements, there exist several drawbacks and challenges, such as pathway data heterogeneity, annotation, regular update and automated image reconstructions, which motivated us to perform a thorough review on popular and actively functioning 24 cell signaling databases. Based on two major characteristics, pathway information and technical details, freely accessible data from commercial and academic databases are examined to understand their evolution and enrichment. This review not only helps to identify some novel and useful features, which are not yet included in any of the databases but also highlights their current limitations and subsequently propose the reasonable solutions for future database development, which could be useful to the whole scientific community.</p>1 aChowdhury, Saikat1 aSarkar, Ram, Rup  uhttps://library.ncl.res.in/content/comparison-human-cell-signaling-pathway-databases-evolution-drawbacks-and-challenges-1