01325nas a2200157   4500008004100000022001400041245017100055210006900226260010600295300001200401490000700413520057700420100002300997700002201020856012501042       2015                        eng d  a0957-416600aCo-catalyzed two-stereocentered hydrolytic kinetic resolution: application to the synthesis of yashabushidiols A and B and the lactone unit of compactin and mevinolin0 aCocatalyzed twostereocentered hydrolytic kinetic resolution appl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a118-1230 v263 a<p>A short and efficient enantioselective synthesis of yashabushidiols A and B and the beta-hydroxy-delta-lactone moiety of compactin and mevinolin with high enantiomeric purity (98% ee) is described starting from commercially available materials. The strategy mainly comprises of iodine-induced intramolecular electrophilic addition of a carbonate occurring in a highly diastereoselective fashion and the Co-catalyzed two-stereocentered hydrolytic kinetic resolution of a functionalized epoxide as the chiral inducing step. (C) 2014 Elsevier Ltd. All rights reserved.</p>1 aGadakh, Sunita, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/co-catalyzed-two-stereocentered-hydrolytic-kinetic-resolution-application-synthesis-0