02343nas a2200241   4500008004100000022001400041245008200055210006900137260006700206300001200273490000700285520151200292653001401804653001701818653002601835653001701861653001301878100002601891700002401917700002101941700002501962856011401987       2015                        eng d  a0959-810300aPorous poly(ethylene glycol)-polyurethane hydrogels as potential biomaterials0 aPorous polyethylene glycolpolyurethane hydrogels as potential bi  a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcMAR  a397-4040 v643 a<p>We report the synthesis of porous poly(ethylene glycol)-polyurethane (PEG-PU) hydrogels using PEG-4000 as a soft segment and 4,4-methylenebis(cyclohexylisocyanate) as a hard segment. The degree of swelling in the hydrogels could be controlled by varying the amount of crosslinking agent, namely 1,2,6-hexanetriol. Structural characterization of the hydrogels was performed using solid-state C-13 NMR and Fourier transform infrared spectroscopy. Wide-angle X-ray diffraction studies revealed the existence of crystalline domains of PEG and small-angle X-ray scattering studies showed the presence of lamellar microstructures. For generating a porous structure in the hydrogels, cryogenic treatment with lyophilization was used. Scanning electron microscopy and three-dimensional micro-computed tomography imaging of the hydrogels indicated the presence of interconnected pores. The mechanical strength of the hydrogels and xerogels was measured using dynamic mechanical analysis. The observed dynamic storage moduli (E) for the equilibrium swollen and dry gels were found to be 0.15 and 4.2 MPa, respectively. Interestingly, the porous PEG-PU xerogel also showed E of 5.6 MPa indicating a similar mechanical strength upon incorporating porosity into the gel matrix. Finally, preliminary cytocompatibility studies showed the ability of cells to proliferate in the hydrogels. These gels show promise for applications as scaffolds and implants in tissue engineering. (c) 2014 Society of Chemical Industry</p>10ahydrogels10apermeability10apoly(ethylene glycol)10apolyurethane10aporosity1 aDivakaran, Anumon, V.1 aTorris, Arun, A. T.1 aLele, Ashish, K.1 aBadiger, Manohar, V.  uhttps://library.ncl.res.in/content/porous-polyethylene-glycol-polyurethane-hydrogels-potential-biomaterials-0