01366nas a2200217   4500008004100000022001400041245014400055210006900199260010600268300001400374490000700388520045900395653001800854653003400872653002000906653001500926100002200941700003200963700003000995856012301025       2015                        eng d  a0040-403900aFormal asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid via Co(III)(salen)-catalyzed two stereocentered HKR of racemic azido epoxide0 aFormal asymmetric synthesis of 2S4R4hydroxypipecolic acid via Co  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a1263-12650 v563 a<p>An efficient formal synthesis of (2S,4R)-4-hydroxypipecolic acid has been achieved in high optical purity (99% ee) from readily available benzaldehyde. The strategy employs an iodine-induced intramolecular cyclization of a carbonate and Co-catalyzed Hydrolytic Kinetic Resolution (HKR) of two stereocentered racemic azido epoxide as the key reactions to construct chiral 1,3-amino alcohol functionality. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aAzido epoxide10aHydrolytic kinetic resolution10alodocyclization10aPiperidine1 aKamble, Rohit, B.1 aGadre, Shubhankar, Haribhau1 aSuryavanshi, Gurunath, M.  uhttps://library.ncl.res.in/content/formal-asymmetric-synthesis-2s4r-4-hydroxypipecolic-acid-coiiisalen-catalyzed-two-0