01295nas a2200193   4500008004100000022001400041245012000055210006900175260010600244300001200350490000700362520048500369100002500854700002300879700002200902700002300924700002400947856013000971       2015                        eng d  a0957-416600aTotal synthesis of (R)-lipoic acid and (S)-lipoic acid via an Mn (III)-salen-catalyzed oxidative kinetic resolution0 aTotal synthesis of Rlipoic acid and Slipoic acid via an Mn IIIsa  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a281-2870 v263 a<p>The asymmetric synthesis of both the antipodes of alpha-lipoic acid is described. The total synthesis of racemic and asymmetric lipoic acid is achieved from propane 1,3-diol. This work reports the use of Mn (III)-salen-catalyzed oxidative kinetic resolution as the key step to obtain enantiomerically pure (R)- and (S)-lipoic acid. The undesired product formed during the resolution can be recycled to achieve the desired isomer. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aPurude, Abhijeet, N.1 aPawar, Kailash, P.1 aPatil, Niteen, B.1 aKalkote, Uttam, R.1 aChavan, Subhash, P.  uhttps://library.ncl.res.in/content/total-synthesis-r-lipoic-acid-and-s-lipoic-acid-mn-iii-salen-catalyzed-oxidative-kinetic-0