01675nas a2200253   4500008004100000022001400041245011200055210006900167260010600236300001400342490000700356520073800363653001501101653001501116653001501131653002001146100002201166700002201188700002401210700002201234700001801256700002801274856011901302       2015                        eng d  a0960-894X00aNovel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity0 aNovel hybrid nocodazole analogues as tubulin polymerization inhi  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a1982-19850 v253 a<p>We describe the design, synthesis and SAR profiling of a series of novel combretastatin-nocodazole conjugates as potential anticancer agents. The thiophene ring in the nocodazole moiety was replaced by a substituted phenyl ring from the combretastatin moiety to design novel hybrid analogues. The hydroxyl group at the ortho position in compounds 2, 3 and 4 was used as the conformationally locking tool by anticipated six-membered hydrogen bonding. The bioactivity profiles of all compounds as tubulin polymerization inhibitors and as antiproliferative agents against the A-549 human lung cancer cell line were investigated Compounds 1 and 4 showed mu M IC50 values in both assays. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aAnticancer10aColchicine10aNocodazole10aTubulin binding1 aKale, Sangram, S.1 aJedhe, Ganesh, S.1 aMeshram, Sachin, N.1 aSantra, Manas, K.1 aHamel, Ernest1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/novel-hybrid-nocodazole-analogues-tubulin-polymerization-inhibitors-and-their-0