01473nas a2200169   4500008004100000022001400041245022700055210006900282260010600351300001200457490000700469520062300476100003101099700001901130700002201149856013201171       2015                        eng d  a0957-416600aEnantioselective synthesis of guggultetrol and D-ribo-phytosphingosine tetraacetate via L-proline catalyzed sequential alpha-aminooxylation/Horner-Wardsworth-Emmons olefination-Sharpless asymmetric dihydroxylation strategy0 aEnantioselective synthesis of guggultetrol and Dribophytosphingo  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a571-5760 v263 a<p>An efficient enantioselective synthesis of two bioactive molecules, that is, guggultetrol and D-ribo-phytosphingosine, is described with high enantioselectivity (&gt;98% ee) starting from commercially available 1-hexadecanol. The synthesis comprises organocatalyzed sequential alpha-aminooxylation of an aldehyde followed by Horner-Wardsworth-Emmons olefination and Sharp less asymmetric dihydroxylation as the key chiral inducing steps. For both syntheses, gamma-hydroxy-alpha,beta-unsaturated ester serves as the common intermediate obtained from proline catalysis. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aVenkataramasubramanian, V.1 aKumar, Senthil1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-guggultetrol-and-d-ribo-phytosphingosine-tetraacetate-l-proline-0