01655nas a2200301   4500008004100000022001400041245008300055210006900138260008300207300001400290490000700304520066300311653002100974653001000995653001401005653003101019653001501050653001701065100002101082700002101103700002101124700001601145700002201161700001901183700001501202700002201217856011401239       2015                        eng d  a1054-252300aDiscovery of rimonabant and its potential analogues as anti-TB drug candidates0 aDiscovery of rimonabant and its potential analogues as antiTB dr  a233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USAbSPRINGER BIRKHAUSERcJUL  a2960-29710 v243 a<p>Rimonabant and its analogues have been synthesized in moderate to good yields using a simple synthetic route. All the newly synthesized compounds were subjected to in vitro screening against M. tuberculosis and M. smegmatis. The most potent analogue JMG-14 exhibits MIC value of 3.13 compared to 3.25 and 50 A mu g/ml for ethambutol and pyrazinamide, respectively. The molecular docking reveals that pyrazole ring, number and position of halogen atoms play a crucial role in deciding interactions with MTCYP-121. These findings open up a new avenue in the search of potent anti-TB drugs with rimonabant and its novel analogue JMG-14 as lead molecules.</p>10aDiaryl pyrazoles10aH37Rv10aMTCYP-12110aMycobacterium tuberculosis10aRimonabant10atuberculosis1 aGajbhiye, J., M.1 aMore, Namita, A.1 aPatil, Manoj, D.1 aUmmanni, R.1 aKotapalli, S., S.1 aYogeeswari, P.1 aSriram, D.1 aMasand, Vijay, H.  uhttps://library.ncl.res.in/content/discovery-rimonabant-and-its-potential-analogues-anti-tb-drug-candidates-0