02187nas a2200265   4500008004100000022001400041245015300055210006900208260005700277300001400334490000700348520121000355653001701565653002001582653001401602653001501616653001901631653002701650100002301677700002301700700002101723700002701744700002401771856012601795       2015                        eng d  a1530-993200aExploring microstructural changes in structural analogues of ibuprofen-hosted in situ gelling system and its influence on pharmaceutical performance0 aExploring microstructural changes in structural analogues of ibu  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcOCT  a1153-11590 v163 a<p>The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle Xray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.</p>10aflurbiprofen10ahexagonal phase10aibuprofen10aketoprofen10aliquid crystal10asustained drug release1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/exploring-microstructural-changes-structural-analogues-ibuprofen-hosted-situ-gelling-0