02248nas a2200253   4500008004100000022001400041245009900055210006900154260010300223300002500326490000600351520128400357653002701641653002601668653001801694653002401712653002301736653002501759653002701784653001701811100002001828700002101848856012501869       2015                        eng d  a1664-302X00aCell scale host-pathogen modeling: another branch in the evolution of constraint-based methods0 aCell scale hostpathogen modeling another branch in the evolution  aPO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLANDbFRONTIERS MEDIA SAcOCT  aArticle Number: 10320 v63 a<p>Constraint-based models have become popular methods for systems biology as they enable the integration of complex, disparate datasets in a biologically cohesive framework that also supports the description of biological processes in terms of basic physicochemical constraints and relationships. The scope, scale, and application of genome scale models have grown from single cell bacteria to multi cellular interaction modeling; host-pathogen modeling represents one of these examples at the current horizon of constraint-based methods. There are now a small number of examples of host-pathogen constraint-based models in the literature, however there has not yet been a definitive description of the methodology required for the functional integration of genome scale models in order to generate simulation capable host-pathogen models. Herein we outline a systematic procedure to produce functional host-pathogen models, highlighting steps which require debugging and iterative revisions in order to successfully build a functional model. The construction of such models will enable the exploration of host-pathogen interactions by leveraging the growing wealth of omic data in order to better understand mechanism of infection and identify novel therapeutic strategies.</p>10aconstraint-based model10aflux balance analysis10ahost-pathogen10amathematical models10aomics-technologies10aoptimization methods10asalmonella typhimurium10atuberculosis1 aJamshidi, Neema1 aRaghunathan, Anu  uhttps://library.ncl.res.in/content/cell-scale-host-pathogen-modeling-another-branch-evolution-constraint-based-methods-1