01447nas a2200217   4500008004100000022001400041245018700055210006900242260010600311300001400417490000700431520050600438653001600944653002700960653003400987653001901021653002401040100002301064700002201087856012001109       2015                        eng d  a0040-403900aShort enantioselective synthesis of ephedrine, amphetamine and their analogues via two stereocentered Co(III)-catalyzed hydrolytic kinetic resolution of racemic syn-benzyloxy epoxide0 aShort enantioselective synthesis of ephedrine amphetamine and th  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6488-64900 v563 a<p>An efficient route for the synthesis of 6 drugs belonging to phenethylamine and amphetamine classes in excellent overall yields and high optical purity has been described. The strategy involves introduction of stereogenic centers by means of two-stereocentered Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of racemic syn-benzyloxy epoxide followed by Pd-catalyzed regioselective cationic hydrogenation of amino alcohols as the key reactions. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aAmphetamine10aCationic hydrogenation10aHydrolytic kinetic resolution10aPhenethylamine10aStereogenic centers1 aLalwani, Komal, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-ephedrine-amphetamine-and-their-analogues-two-0