02107nas a2200241   4500008004100000022001400041245009500055210006900150260007100219300001200290490000700302520123300309653002401542653002401566653002201590653001701612653003301629653001501662100001701677700002501694700001901719856012701738       2016                        eng d  a0091-403700aCrosslinked polymer embedded Cu/Ag for comparative drug adsorption and kinetics evaluation0 aCrosslinked polymer embedded CuAg for comparative drug adsorptio  aKARL JOHANS GATE 5, NO-0154 OSLO, NORWAYbTAYLOR & FRANCIS AScJAN  a285-2930 v653 a<p>Two-dimensional crosslinked polymer (2-DCP) was synthesized for evaluation of drug adsorption and kinetics thereof. Further, polymer properties were evaluated and parameters such as contact time and adsorption isotherm were also studied. Herein, contact time demonstrated 83% and 85% of drug loading in an acidic medium for two-dimensional crosslinked polymer embedded copper and silver (2-DCP-Cu/Ag), respectively in 24h. Initial 4h is the exponential drug loading period whereas drug loading was increased gradually after 4h. Salbutamol loading was well-fitted to Langmuir adsorption isotherm, which indicated a monolayer drug adsorption with respect to 2-DCP-Cu/Ag. Pseudo first- and pseudo second-order kinetics was evaluated to perceive the drug adsorption mechanism and equilibrium adsorption capacity. Monolayer drug adsorption with chemisorption mechanism was observed for 2-DCP-Cu/Ag. In addition to this, decomposition temperature of polymer was 440 and 325 degrees C while glass transition temperature of polymer was 280 and 200 degrees C before and after metal modification, respectively. (A=aqueous phase; B=organic phase; C=drug solution; D=drug loaded polymer; E=enlarged drug loaded polymer.) [GRAPHICS] .</p>10aAdsorption isotherm10aadsorption kinetics10acrosslink polymer10adrug loading10alangmuir adsorption isotherm10asalbutamol1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku  uhttps://library.ncl.res.in/content/crosslinked-polymer-embedded-cuag-comparative-drug-adsorption-and-kinetics-evaluation-1