02126nas a2200229   4500008004100000022001400041245016200055210006900217260007100286300001200357490000700369520122300376100001801599700001601617700002401633700002001657700002301677700002001700700002601720700002201746856012801768       2016                        eng d  a1525-779700aTunable nanocarrier morphologies from glycopolypeptide-based amphiphilic biocompatible star copolymers and their carbohydrate specific intracellular delivery0 aTunable nanocarrier morphologies from glycopolypeptidebased amph  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a466-4750 v173 a<p>Nanocarriers with carbohydrates on the surface represent a very interesting class of drug-delivery vehicles because carbohydrates are involved in biomolecular recognition events in vivo. We have synthesized biocompatible miktoarm star copolymers comprising glycopolypeptide and poly(e-caprolactone) chains using ring-opening polymerization and ``click chemistry''. The amphiphilic copolymers were self-assembled in water into morphologies such as nanorods, polymersomes, and micelles with carbohydrates displayed on the surface. We demonstrate that the formation of nanostructure could be tuned by chain length of the blocks and was not affected by the type of sugar residue. These nanostructures were characterized in detail using a variety of techniques such as TEM, AFM, cryogenic electron microscopy, spectrally resolved fluorescence imaging, and dye encapsulation techniques. We show that it is possible to sequester both hydrophobic as well as hydrophilic dyes within the nanostructures. Finally, we show that these noncytotoxic mannosylated rods and polymersomes were selectively and efficiently taken up by MDA-MB-231 breast cancer cells, demonstrating their potential as nanocarriers for drug delivery.</p>1 aPati, Debasis1 aDas, Soumen1 aPatil, Naganath, G.1 aParekh, Nimisha1 aAnjum, Dalaver, H.1 aDhaware, Vinita1 aAmbade, Ashootosh, V.1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/tunable-nanocarrier-morphologies-glycopolypeptide-based-amphiphilic-biocompatible-star-1