01360nas a2200157   4500008004100000022001400041245025700055210006900312260007100381300001200452490000700464520056600471100001901037700002401056856012201080       2016                        eng d  a1523-706000aO-Quinone methides via oxone-mediated benzofuran oxidative dearomatization and their intramolecular cycloaddition with carbonyl groups: an expeditious construction of the central tetracyclic core of integrastatins, epicoccolide A, and epicocconigrone A0 aOQuinone methides via oxonemediated benzofuran oxidative dearoma  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a612-6150 v183 a<p>The intramolecular cycloaddition of o-quinone methides (o-QMs) with a carbonyl group has been envisaged and executed successfully in the context of constructing the complex and rare [6,6,6,6]-tetracyclic core found in the integrastatins, epicoccolide A, and epicocconigrone A. These transient o-QMs were generated easily from the oxidative dearomatization of the corresponding C2-(aryl)benzofuran by employing Oxone in acetone-water at rt. The subsequent cydoaddition with the carbonyl (or conjugated olefin) present on the C2-aryl group was spontaneous.</p>1 aMore, Atul, A.1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/o-quinone-methides-oxone-mediated-benzofuran-oxidative-dearomatization-and-their-1