01490nas a2200253   4500008004100000022001400041245017700055210006900232260010600301300001200407490000700419520047900426653001800905653002700923653001400950653000900964653002300973100001600996700002301012700002501035700002301060700002201083856013101105       2016                        eng d  a0040-403900aPd-catalyzed reductive cleavage of N-N bond in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates with PMHS: application to a formal enantioselective synthesis of (R)-sitagliptin0 aPdcatalyzed reductive cleavage of NN bond in dibenzyl1alkylhydra  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a684-6870 v573 a<p>An environmentally benign approach involving Pd-catalyzed reductive N-N bond cleavage in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates leading to the synthesis of N-(tert-butoxy)carbamates under very mild conditions has been described. PMHS serves as an inexpensive source of hydride in MeOH/deionized H2O medium. This protocol has been successfully applied in the formal synthesis of (R)-sitagliptin, an anti-diabetic drug. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aanti-Diabetic10aEnvironmentally benign10aHydrazine10aPMHS10aReductive cleavage1 aDey, Soumen1 aGadakh, Sunita, K.1 aAhuja, Brij, Bhushan1 aKamble, Sanjay, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/pd-catalyzed-reductive-cleavage-n-n-bond-dibenzyl-1-alkylhydrazine-12-dicarboxylates-pmhs-0