01316nas a2200157   4500008004100000022001400041245016700055210006900222260010600291300001200397490000700409520056900416100002100985700002601006856012601032       2016                        eng d  a0957-416600aFormal synthesis of pinolide via L-proline-catalyzed sequential alpha-aminooxylation, horner-wadsworth-emmons olefination and sharpless asymmetric dihydroxylation0 aFormal synthesis of pinolide via Lprolinecatalyzed sequential al  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a142-1470 v273 a<p>A convergent, formal enantioselective synthesis of pinolide, a new nonenolide, has been achieved with high enantiomeric purity (99% ee) starting from readily available raw materials. The main highlight of the synthetic strategy is the application of L-proline catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination of an aldehyde, Sharpless asymmetric dihydroxylation and Steglich esterification as the key steps for the construction of a key chiral intermediate of the target molecule. (C) 2016 Elsevier Ltd. All rights reserved.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/formal-synthesis-pinolide-l-proline-catalyzed-sequential-alpha-aminooxylation-horner-0