@article {46137,
	title = {Neural anti-inflammatory natural product periconianone A: total synthesis and biological evaluation},
	journal = {European Journal of Organic Chemistry},
	year = {2019},
	month = {APR },
	pages = {2376-2381},
	type = {Article},
	abstract = {<p>Total synthesis of periconianone A, an eremophilane-type sesquiterpenoid with impressive neural anti-inflammatory potential, has been accomplished. Diels-Alder/aldol strategy to construct tetrahydro-naphthalene-2,6-dione scaffold, allylic oxidation of dienone using DBU/O-2 and postulated biomimetic aldol reaction to construct 6/6/6 tricyclic system are the highlights of the present synthesis. Furthermore, the synthesized (+/-)-periconianone A and two close analogs were tested for their neural anti-inflammatory activity using various assays. In the course of our study we found a structurally simplified analog is superior to (+/-)-periconianone A.</p>
},
	keywords = {Aldol, Allylic oxidation, Biological evaluation, Cytotoxicity, Diels-Alder, Periconianone A},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201900048},
	author = {Kalmode, Hanuman P. and Patil, Suhag S. and Handore, Kishor L. and Athawale, Paresh R. and Dandela, Rambabu and Verma, Abhishek Kumar and Basu, Anirban and Reddy, D. Srinivasa}
}
@article {48030,
	title = {Construction of tetrahydrobenzo[f]quinoline scaffolds via polar [4+2]-Cycloaddition reaction with arynes as dienophiles},
	journal = {Tetrahedron Letters},
	volume = {101},
	year = {2022},
	month = {JUL},
	pages = {153901},
	type = {Article},
	abstract = {<p>
	A transition-metal-free route has been developed for the direct synthesis of biologically significant tetrahydrobenzo[f]quinoline scaffolds. The reaction features polar [4 + 2] Diels-Alder cycloaddition reaction of arynes with a well-designed diene N-Boc protected vinyl tetrahydropyridine, followed by the isomerisation of the double bond leading to the formation of tetrahydrobenzo[f]quinoline scaffolds in good to moderate yields.</p>
},
	keywords = {Aryne, Diels-Alder, Diene, Tetrahydrobenzo[ f ]quinoline},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2022.153901},
	author = {Pandya, Virat G. and Mhaske, Santosh B.}
}
