@article {44204,
	title = {Beyond hydrofunctionalisation: a well-defined calcium compound catalysed mild and efficient carbonyl cyanosilylation},
	journal = {Chemistry-A European Journal},
	volume = {24},
	year = {2018},
	month = {JAN},
	pages = {1269-1273},
	type = {Article},
	abstract = {<p>Organocalcium compounds have been reported as efficient catalysts for various transformations, for cases in which one of the substrates contained an E-H (E=B, N, Si, P) bond. Here, we look at the possibility of employing an organocalcium compound for a transformation in which none of the precursors has a polar E-H bond. This study demonstrates the utilization of a well-defined amidinatocalcium iodide, [PhC(NiPr)(2)CaI] (1) for cyanosilylation of a variety of aldehydes and ketones with Me3SiCN under ambient conditions without the need of any co-catalyst. The reaction mechanism involves a weak adduct formation between 1 and Me3SiCN leading to the activation of the Si-C bond, which subsequently undergoes sigma-bond metathesis with a C=O moiety. Such a mechanistic pathway is unprecedented in alkaline earth metal chemistry. Experimental and computational studies support the mechanism.</p>},
	keywords = {Ca catalysis, carbonyls, cyanosilylation, Density functional calculations, transition-metal free},
	issn = {0947-6539},
	doi = {10.1002/chem.201705795},
	author = {Yadav, Sandeep and Dixit, Ruchi and Vanka, Kumar and Sen, Sakya S.}
}
@article {49275,
	title = {Strategies employing transition-metal free conditions for C-C bond formation in indoles},
	journal = {ChemistrySelect},
	volume = {9},
	year = {2024},
	month = {SEP},
	pages = {e202403280},
	type = {Review},
	abstract = {<p>
	Indole motifs are omnipresent in nature and can be found in many natural products as well as pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic of interest for the organic and medicinal chemist community for decades. In this review, we have emphasized the functionalization of indoles via transition-metal-free approaches. This review touches on many aspects in different sub-sections, which gives a proposition of the tactics employed for the functionalization of indoles and an overview of the road ahead. In this review, essentially transition-metal-free conditions for C-C bond formation reactions in indoles has been explored. This review describes various approaches of functionalization at the C-2, C-3, C-4 and C-7 position of indoles which comprises arylation, alkenylation, acylation, formylation, alkylation, bisindolyl and cyclization strategies. Also, strategies incorporating N-alkylation/arylation has also been covered. image</p>
},
	keywords = {Alkylation, Arylation, formylation, Indole, transition-metal free},
	issn = {2365-6549},
	doi = {10.1002/slct.202403280},
	author = {Ghodake, Balaji M. and Paul, Sayantan and Bhattacharya, Asish K.}
}
