@article { ISI:000244127600016,
	title = {NaIO4-mediated asymmetric bromohydroxylation of alpha,beta-unsaturated carboxamides with high diastereoselectivity: a short route to (-)-cytoxazone and droxidopa},
	journal = {Tetrahedron Letter},
	volume = {48},
	number = {8},
	year = {2007},
	month = {FEB},
	pages = {1375-1378},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	type = {Article},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>The NaIO4-mediated asymmetric bromohydroxylation of alpha,beta-unsaturated carboxamides was achieved using lithium bromide as the bromine source under acidic conditions at rt to afford the corresponding chiral alpha-bromo-beta-hydroxy carboxamides. Excellent yields (77-90\%) and diastereoselectivities (up to 10:1) along with exclusive control over regio- as well as anti-selectivity are the main features with a good scope of substrates. The method has successfully been applied in the enantioselective syntheses of two biologically important molecules, viz (-)-cytoxazone and L-threo-DOPS (droxidopa). (c) 2007 Elsevier Ltd. All rights reserved.</p>},
	keywords = {asymmetric bromohydroxylation, Carboxamide, cytoxazone, droxidopa, NaIO4},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2006.12.109},
	author = {George, Shyla and Narina, Srinivasarao V. and Sudalai, Arumugam}
}
