@article { ISI:000244732800019,
	title = {Stereoselective synthesis of 3-alkylidene/alkylazetidin-2-ones from azetidin-2,3-diones},
	journal = {Tetrahedron},
	volume = {63},
	number = {11},
	year = {2007},
	month = {MAR},
	pages = {2524-2534},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	type = {Article},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>Azetidin-2,3-diones have been used as synthons for the synthesis of C-3 alkylidene/alkylazetidin-2-ones. Some of the 3-alkylazetidin-2-ones are well known for their cholesterol absorption inhibitor activity. A regio and stereoselective Grignard reaction on a keto group followed by dehydration using PPh3/CCl4 reagent is a key step in this synthesis. Hydrogenation of the 3-alkylideneazetidin-2-ones provided stereoselectively cis-3-alkylazetidin-2-ones in very good yields. (c) 2006 Published by Elsevier Ltd.</p>},
	keywords = {3-diones, azetidin-2, azetidin-2-ones, beta-lactam, Grignard reaction},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2006.12.010},
	author = {Tiwari, Dharmendra Kumar and Shaikh, Ashif Y. and Pavase, Laxmikant S. and Gumaste, Vikas K. and Deshmukh, Abdul Rakeeb A. S.}
}
@article {49599,
	title = {Unlocking thermodynamic enolate for kinetically controlled desymmetrizing vinylogous (4+1) carbospiroannulation},
	journal = {Chemistry-A European Journal},
	volume = {31},
	year = {2025},
	month = {MAY},
	type = {Article},
	abstract = {<p>
	An unprecedented thermodynamically unfavorable (4+1) deysmmetrizing spiroannulation through a thermodynamic enolate intermediate, enabling a single-step synthesis of ubiquitous scaffolds such as all-carbon chiral spirocycles, is disclosed. In this spiroannulation, we present a vinylogous organocatalytic enantioselective desymmetrizing (4+1) cycloaddition approach involving alkylidene malononitrile and cyclopent-1,3-dienone. This carbospiroannulation method produces functionally enriched spiro[4,4]nonane structures with three stereocenters, has presented good-to-high yields and enantiomeric ratios. Detailed DFT calculations reveal an intriguing reaction mechanism, which validates our observations.</p>
},
	keywords = {3-diones, alkylidene malononitrile, cyclopent-1, quaternary stereocenters, spiro compounds, thermodynamic enolate},
	issn = {0947-6539},
	doi = {10.1002/chem.202500671},
	author = {Singh, Sanjay and Singh, Abhijeet and Pandya, Rinu and Vanka, Kumar and Singh, Ravi P.}
}
